FLASH CHROMATOGRAPHY AT AECS                         

Milligram to tonnes per annum are available when using the novel, Gyan Flash Chromatograph which is distributed by AECS


Existing Biotage, Argonaut, Isco etc Flash Chromatography Instrumentation can be simply updated to use Jumbo or EasiFlash pumps, cartridges and solid sample injectors. These innovative, patented Gyan products will often significantly outperform original pumps, cartridges and injectors, are much easier to use and yet are available from AECS at extremely competitive prices


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About Gyan




EasiSoft from Gyan

EasiSoft can operate both on-line (pump control and UV display for example), and off-line (method development)

Here is an overview of the features incorporated into the software

On-Line Features

Continuous on-line monitor of UV output, pump gradient, pressure variation

On-Line pump control Via RS232 provides:

Start Pump (eg from autosampler)
Stop Pump (eg from fraction collector)
Start signal from pump (eg to fraction collector)
Synchronisation of master and slave pumps
Ready signals out
Automatic recognition of cartridge type and automatic set of optimum flow rate (requires accessory)
Signal output for valve switching (eg auto back-flush)
Signal output to flow divert valve (eliminates need for fraction collector for simple samples)
Output to solvent selection valve
Display of total working hours of pump
Alarm for overpressure
Graph of pressure variation (requires accessory)
Graph of gradient
Hold and re-start of gradient
Graphical gradient programming
Infinite programs in memory

All programs may be created within the software and downloaded to EasiFlash or EasiPump.

The same software can be used with all Gyan pumped products!

Off-Line Features

Helps the user develop new separations and purifications by:

Flash Chromatography simulation from TLC runs
Obtain simulated flash chromatogram using the same solvents and silica used in a TLC run. Use to forecast good approximation of time to collect fractions

Solvents Database
Contains a database of the most commonly used flash chromatography solvents. Containing useful information such as eluting strength, density and other chemical and physical properties important for the user and software. Uses may input their own solvents into the database.

Selection of alternative solvents
Once a separation is developed with a specific solvent mix, EasiFlash can calculate a new mixture in which a solvent is replaced with another one providing the same eluting power. Particularly useful if one solvent is unobtainable, dangerous or expensive!

Scale-Up predictions
Using data from a small column, it is possible to obtain the parameters necessary to scale-up to a larger column and obtain the same separation

Loading of data from TLC runs
From the image of a TLC plate or data obtained from a small column, the predicted loading capacity of all column sizes is available

Optimum flow rate calculations
EasiSoft will calculate the optimum flow rate to be used in different conditions to achieve the best results with each cartridge size


AECS can offer "Total Preparative Solutions™" packages, and can therefore assist you in your choice of the best preparative technology, be it Flash Chromatography, Preparative / Process HPLC, or HSCCC, or even maybe a two / three dimensional combination.

AECS can also offer contract method development or final product preparation to non-GMP or GMP standards

  



            

For Additional information on the EasiSoft


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