Milligram to tonnes per annum are available when using the novel, Gyan Flash Chromatograph
which is distributed by AECS.
Existing Biotage, Argonaut, Isco etc Flash Chromatography Instrumentation
can be simply updated to use Jumbo or EasiFlash pumps, cartridges and solid sample
injectors. These innovative, patented Gyan products will often significantly outperform
original pumps, cartridges and injectors, are much easier to use and yet are available
from AECS at extremely competitive prices
: Patented Axial & Radial Compression Improves Efficiency And Allows
Up To 80g Injections Now..... 250+ g Soon !!!
Unique 360 degree compression allows better resolution and higher sample
loading up to 80g depending on the separation
When you need to scale-up
and go to larger flash cartridge sizes, it is important to have a system
which is easy to use, provides the correct compression and allows easy
removal of cartridges after use.
The new patented JumboFlash from Gyan provides all these features plus
a variety of columns, pre-columns and solid sample option
Patented Design - 360 degree compression
The JumboFlash system uses a unique patented system to solve the compression
problem of larger cartridges. By compressing the cartridge between two
stainless steel shells, it is compressed from all directions.
Conventional systems compress either radially or axially, both of which
can compromise performance.
The Gyan system maintains the homogeneity of the packing material improving
the performance of the cartridge.
Turning the bar on the top of the holder applies an axial compression
while the two shells compress the cartridge inwards. The design allows
easy removal of the used cartridge after the run even if has swollen
Jumbo Flash consists of a cartridge holder, a steel jacket and screw
compression mechanism. The solvent and sample inlet is through the centre
of the mechanism.
The cartridge is placed on the base.The two wall shells Pivot from the
base and surround the cartridge
The compression mechanism is placed in the top of the cartridge and connects
to the two wall shells as shown below
As the compression mechanism tightens, the shape of the holder cause it
to pull the jacket inwards causing radial pressure at the same time as
applying pressure on the ends of the column.
To release the cartridge after use, simply reverse the process and remove
the cartridge without any force being required
The design allows 80mm diameter cartridges of different lengths to be
accommodated in the same holder. In addition to standard lengths, custom
bed depths are available to order thus optimising separations and saving
money by not buying unnecessary silica.
For samples that need to be pre-absorbed on silica, the
Sample cartridges can be used. These are available with special holders
that fit directly on to the JumboFlash holder with a zero dead volume
System Part Numbers
JF0001 Holder for large dimension cartridges (80mm i.d.) Uses both radial
and axial compression and allows easy removal of swollen cartridges. Used
to purify up to 40g
A special patented frit system ensures that the sample is placed uniformly
on the column, optimising the conditions for a good separation
Ease of use
A four way valve introduces liquid samples on to the top of the column
without the need to stop the pump.
Using EasiSoft software it is possible to scale up directly from separations
made with smaller cartridges
JumboFlash is quickly being developed further. For further details, please
register your interest by clicking here We will be pleased to discuss
you specific requirements and provide a quotation.
AECS can offer "Total
Preparative Solutions™" packages, and can therefore assist
you in your choice of the best preparative technology, be it Flash Chromatography,
Preparative / Process HPLC, or HSCCC, or even maybe a two / three dimensional
AECS can also offer contract method development or final product preparation
to non-GMP or GMP standards