WHAT MAKES THE NEW QUATTRO CCC™ MK 5 RANGE SO SPECIAL

Index

 

The panoramic picture above shows the NEW Quattro CCC™ Mk 5 LabPrep™ in our Contract Feasibility Research, 2D CCC/HPLC Method Development Work-Station ( for Free Feasibility Study options please press button "New For 2005" on Index Page )

From the above picture it can be seen that the NEW Quattro CCC™ Mk 5 LabPrep™ is basically a simple addition to any standard solid / liquid chromatography instrumentation set-up. It makes no difference if you are adding CCC on laboratory or process scale, or to either a high or low pressure chromatography system, you simply treat the CCC as a column. You utilise your standard non-column ancillary components, ie injector ( near CCC ), pump, switching valves, detector, fraction collector, control and data system etc as you would normally 

The only difference between utilising a prep HPLC or Flash column and a CCC is that in CCC the column is a mechanical instrument, with a tube filled with your chosen two immiscible liquids, instead of a tube filled with your selection of solid particles and a liquid.

BUT CCC has the HUGE ADVANTAGE that it cannot be poisoned like an expensive HPLC ( or cheaper Flash ) columns. Plus you can have a new column for each preparation for only the cost of the solvent. In addition, a typical Quattro CCC™ preparation will use much lower flow rates and considerably less solvent than either Prep HPLC or Flash for the same mass injected.

As you can see from above, a Quattro CCC™ Mk 5 LabPrep™ instrument is not much bigger than a standard lab HPLC pump etc, yet is capable of 5 to 20g ( occasionally up to 40 g ) per 1000 ml capacity, but with laboratory scale of flow rates, that are readily available from a simple, standard analytical, 10 ml / min laboratory type HPLC system.

As you know for high resolution, 5 to 40 g loadings, it would require large flow HPLC prep pumps ( 100 to 1000+ mls per min ), an enormous amount more solvent, and expensive prep process scale hplc columns, with expensive axial or radial compression process column hardware system. At this 5 to 40 g loading scale for high resolution prep HPLC prep, usually your equipment requires expensive hardware to intrinsically safe standard, because of the large volume of solvents used. It is a EEC requirement by law to utilise Intrinsically Safe Instrumentation if total organic solvent usage exceeds 5000ml for the process. This is a considerable restriction for Flash and Prep HPLC, but much less so in CCC.

For those not familiar with Prep HPLC column loading capacity, we have included a comparison of "On-Column Loadings" for Baseline Resolution / Simple Heart-Cut / Prep Overload + Typical Flow Rates for a variety of laboratory scale HPLC prep columns ( bore in mm x length in mm ).

COLUMN           LOADINGS                         FLOW-RATES
21 x 50                5mg / 20 mg / 80 mg.              8 to 20 ml / min
21 x 250              25mg / 100 mg / 400 mg.         8 to 20 ml / min
30 x 250              50mg / 200 mg / 800 mg.         12 to 30 ml / min
50 x 250              150mg / 600 mg / 2400 mg.     30 to 100 ml / min


As you can see for pre-packed prep HPLC columns, the largest of which is typically 50 mm id, the "Overload Injection Loading" is only just over 2 grams, and yet you could already be utilising flows of 100 ml / min. Such a prep could probably be achieved with a 100 to 400 ml Quattro CCC™ coil, with flows of only 2 to 10 ml / min, and a very considerably reduction in total solvent usage
 
Scale this up to Process Scale Chromatography, and the cost savings are very considerable, for both ancillary equipment and solvent usage.

With CCC, equivalent prep resolution is available MUCH MORE CHEAPLY, and one CCC can be reverse or normal or ion exchange, or ligand / affinity etc at fraction purchase or running cost, plus you can renew column contents each injection, and easily wash / sterilise between new preparations to meet GMP.




  AECS-QuikPrep™, P O Box 80, Bridgend, UK, CF31 4XZ            Tel : (0) 1656 782 985 Fax : (0) 1656 789 282
For Contact Page Please : Click Here                                          Web Site : www.ccc4labprep.com
 

Quattro CCC™ Mk 5 Chromatography Please Call For Pricing

QuikPrep™, Quattro CCC™ Mk 5, Liquid-Liquid Chromatography Systems

Part Number Description Price £
QP0001 QuikPrep™ inclusive of instrument chassis, yoke, platter, basic electrics + electronics + motor etc. Exclusive of bobbins, coils, flying leads, heater temperature control + digital temperature readout and digital speed readout. Call
  Coil Options include bores of 0.5, 0.8, 1.0, 1.5, 2.0, 2.4, 3.0, 3.2, 3.7, 4.0 in PTFE or Stainless Steel etc tubing. All coils are potted in aircraft adhesive and come with a guarantee.  
QP125/1/1.5PTFE Example: Option A of coil possibilities. 125 ml total as one of 125 ml PTFE 1.5 mm id tubing, single coil on one bobbin + counter balance + flying leads. Mass injection loading approx 0.6 to 2.5+ grams Call
QP500/2/2.2SS Example: Option B of coil possibilities. 500 ml total as two of 250 ml Stainless Steel 2.2 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 2.5 to 10+ grams Call
QP002/1 Option of having 2 coils on one bobbin, 2 in total Call
QP004/2 Option of having 2 coils on two bobbin, 4 in total Call
QP0Temp Option of temperature control and digital temperature readout Call
QP0Speed Option of digital speed readout Call

ADD A PREPPLUS™ TO ADD UP TO 1600ml TO YOUR CAPACITY

LabPrep™, Quattro CCC™ Mk 5, Liquid-Liquid Chromatography Systems

Part Number Description Price £
LP0001 LabPrep™ inclusive of instrument chassis, yoke, platter, basic electrics + electronics + motor etc. Exclusive of bobbins, coils, flying leads, heater temperature control + digital temperature readout and digital speed readout. Call
  Coil Options include bores of 0.5, 0.8, 1.0, 1.5, 2.0, 2.4, 3.0, 3.2, 3.7, 4.0, 5.0, 6.0, 7.0 to 10.0 + in PTFE or Stainless Steel etc tubing. All coils are potted in aircraft adhesive and come with a guarantee.  
LP800/2/2.0PTFE Example: Option A of coil possibilities. 800 ml total as two coils of 400 ml PTFE 2.0 mm id tubing, single coil on each of two bobbins + flying leads. Mass injection loading approx less than 4 to 16+ grams Call
LP1000/2/2.2SS Example: Option B of coil possibilities. 1000 ml total as two of 500 ml Stainless Steel 2.16 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 5.0 to 20+ grams Call
LP1600/2/3.7SS Example: Option C of coil possibilities. 1600 ml total as two of 800 ml Stainless Steel 3.7 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 8.0 to 32+ grams Call
LP004/2 Option of having 2 coils on two bobbin, 4 in total Call
LP0Temp Option of temperature control and digital temperature readout Call
LP0Speed Option of digital speed readout Call

ADD A PREPPLUS™ TO ADD UP TO 1600ml TO YOUR CAPACITY

PilotPrep™, Quattro CCC™ Mk 5 Liquid-Liquid Chromatography Systems

Part Number Description Price £
PP0001 PilotPrep™ inclusive of instrument chassis, yoke, platter, basic electrics + electronics + motor etc. Exclusive of bobbins, coils, flying leads, heater temperature control + digital temperature readout and digital speed readout. NO aluminium, ALL Stainless Steel construction with INTRINSICALLY SAFE BUILD CRITERIA, for PROCESS PRODUCTION Call
  Coil Options include bores of 0.5, 0.8, 1.0, 1.5, 2.0, 2.4, 3.0, 3.2, 4.0, 5.0, 6.0, 7.0 to 10.0 + in PTFE or Stainless Steel etc tubing. All coils are potted in aircraft adhesive and come with a guarantee.  
PP1600/2/2.0PTFE Example: Option A of coil possibilities. 1600 ml total as two of 800 ml PTFE 2.0 mm id tubing, single coil on each bobbin + flying leads. Mass injection loading approx 8.0 to 32+ grams Call
PP3200/2/3.7SS Example: Option B of coil possibilities. 3200 ml total as two of 1600 ml Stainless Steel 3.7 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 16.0 to 64+ gram Call
PP004/2 Option of having 2 coils on two bobbin, 4 in total Call
PP0Temp Option of temperature control and digital temperature readout Call
PP0Speed Option of digital speed readout Call

ADD A PREPPLUS™ TO DOUBLE YOUR CAPACITY

ProcessPrep™, Quattro CCC™ Mk 5 Ton/Annum, Liquid-Liquid Chromatography Systems

Part Number Description Price £
PRP0001 ProcessPrep™ Modules of 2000 or 3000 inclusive of stainless steel yoke, platter. Exclusive of bobbins, coils, flying leads, basic electronic + electrics, motor, heater temperature control + digital temperature readout and digital speed readout. All component structures are stainless steel, NO aluminium used in construction Call
  Coil Options include bores of 0.5, 0.8, 1.0, 1.5, 2.0, 2.4, 3.0, 3.2, 4.0, 5.0, 6.0, 7.0 to 10.0 + in PTFE or Stainless Steel etc tubing. All coils are potted in aircraft adhesive and come with a guarantee.  
PRP1600/2/2.0PTFE Example: Option A of coil possibilities. 1600 ml total as two of 800 ml PTFE 2.0 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 8.0 to 32+ grams. All Bobbin structures are stainless steel, NO aluminium used in construction Call
PRP3200/2/3.7SS Example: Option B of coil possibilities. 3200 ml total as two of 1600 ml Stainless Steel 3.7 mm id tubing, single coil on each of two bobbin + flying leads. Mass injection loading approx 16.0 to 64+ grams. All Bobbin structures are stainless steel, NO aluminium used in construction Call
PRP004/2 Option of having 2 coils on two bobbin, 4 in total Call

ProcessPrep™ Ton/Annum, Liquid-Liquid Chromatography Systems

What is a PrepPlus™ ?


A PrepPlus™ is a additional, cased rotor module, that simply bolts to the side of your existing Quattro CCC™ Mk 5 and is controlled and driven by your existing motor and control electronics. This allows low-cost, very cost-effective, modular expansion of the capacity and throughput of all Quattro CCC™ Mk 5's; a feature unique to the Quattro CCC™ Mk 5

For both the QuikPrep™ and LabPrep™, their PrepPlus™ are aluminium constructed, LabPrep™ sized modules, thus the capacity could be increased by up to 1600 ml, to give a total capacity of a LabPrep™ + PrepPlus™ of approximately 3200ml with 16 to 64 g loading capacity.

For the PilotPrep™, this PrepPlus™ is a stainless steel constructed PilotPrep™ sized module, thus the capacity could be increased by up to 3200 ml, to give a total capacity of a PilotPrep™ + PrepPlus™ of approximately 6400ml with 32 to 128 g loading capacity. As the flow rates used in a Quattro CCC™ are a fraction of that used in a process HPLC, the overall cost of 100g capacity CCC is also much less expensive that a 1000ml/min prep HPLC installation capable of 100+g "on-column" loadings, inclusive of pump, hplc column, etc, PLUS YOU HAVE NO ONGOING SOLID HPLC STATIONARY PHASE COSTS, OR CHANCE TO POISON YOUR SOLID STATIONARY PHASE, OR FOR THIS SOLID PHASE TO ADSORB / CHEMICALLY ALTER YOUR TARGET !!!.



ProcessPrep™ Ton/Annum, Liquid-Liquid Chromatography Systems
 
Consult AECS-QuikPrep™ For Your Full Options Capabilites
 
NO REDUNANCY, A QuikPrep™ change bobbins or add PrepPlus™
 
NO REDUNANCY, A LabPrep™ change bobbins or add PrepPlus™
 
NO REDUNANCY, A PilotPrep™ change bobbins or add PrepPlus™
 
Modular Construction, Scale-up as predictable as Flash or HPLC

Request information for Quattro CCC™

Picture shows the NEW modular Quattro CCC™ QuikPrep™ Mk 5
All QuikPrep™ can be expanded to a LabPrep™ or a PilotPrep™

Typical Quattro CCC™ “on-column” mass loadings are 5 to 20+ g per 1000ml CCC capacity.

          ProcessPrep™ All S/Steel Construction

         Multiple Modules        :       2,000ml Call

                6,000ml Call      :       24,000ml Call

   Please Contact AECS-QuikPrep™ For More Details




Don’t Forget we can custom synthesis your research HPLC / Flash Achiral or Chiral Phase in up to 5 Kilo batch sizes, and our pre-packed 2.1 to 55 mm id HPLC columns are amongst the most efficient in the world.

Can our competitor’s 300 Å, 5µm, C4 column yield 85,000 to 105,000 p/m in
21 mm x 250 columns? A QuikPrep Enhanced™ HPLC Prep Column Can !!!

AECS-QuikPrep™ specialises in Generic Optimisation Techniques for Two Dimensional CCC / HPLC, we also offer REFUNDABLE FEASIBILITY STUDIES!



Request information for Quattro CCC™

AECS-QuikPrep™           
P O Box 80,  Bridgend
S. Wales, UK
CF31 4XZ