ccc4labprep.com

CCC4LABPREP FOR THE QUATTRO CCC™ AND ADVANCED COUNTER CURRENT CHROMATOGRAPHY 
 

2D Liquid   
                                               

New Products

Index

Why use CCC
CCC complimentary HPLC

Applications 2005

Applications 1
Natural Product Bioactitives
Isocratic vs Step Gradient
Novel Alkaloids

Applications 2
Polyphenols
Engine Oil Additives, Isocratic
Effect Coil Volume
Why need Gradients in CCC
Comparison to Flash Chrom
Which Biphasic Solvents
Linear Gradients
pH Modification Part Coeff
Step Gradient
Linear Gradient RP
Comparison NP to RP
Unknown Bioactivites
Engine Oil Additives :Gradient
LC-FID

Specifications 
Retail Prices
CCC Intro
Company Intro
Publications
Lab Scale
Pilot Process
Rio CCC 2001









NEW QUATTRO CCC™ MK V QUIKPREP™

Ten years of AECS-QuikPrep™ research has resulted in the latest modular, minimal footprint Quattro CCC™ Mk V QuikPrep™.

AECS-QuikPrep™ novel 2D preparative strategies could achieve for your company, huge process etc cost savings. Laboratory sized method development optimisation studies based on our QuikPrep™ CCC and HPLC / Flash Chromatography products can easily be scaled to multiple tonne pre annum production.

Request information for Quattro CCC™

Company Introduction



       Les                  
                   Dr Les Brown                                    


Dr Les Brown, the proprietor of AECS, founded the company as a chromatography methodology and contract instrument design consultancy in October 1983.

Since that time the company has continued its core business of contract research method development and achiral plus chiral preparative / process chromatography.

Over twenty years later, AECS still offers these services in confidence, on a commercial, individual project basis.

In addition AECS has designed an evaporative light scatter detector, an LC-FID / LC-MS interface, plus possibly the world’s first peltier HPLC column chiller for chiral chromatography and several other projects.

Both instrumentation companies and blue chip non-instrumentation companies requiring custom production of instrumentation not commercially available, have contracted these projects.

From 1991, AECS in addition to the above, diversified into the supply and sale of chromatography consumables, plus novel instrumentation, both of it’s own design and imported niche products.

More recently AECS has assisted MicroSolv Technology Inc., establish a range of micro-analytical, analytical and preparative HPLC phases and column technologies. The HPS ( low trace metal end-capped ) / hQ ( low trace metal non end-capped ) type B ( Silanol surface ) and the novel Type C™ ( Silica-Hydride surface ) phases have assisted MicroSolv to diversify from one of the world’s major CE / CEC consumable suppliers, into a new force in HPLC. MicroSolv was awarded recognition for its unique patented Type C™ phases, being one of the most significant new product releases at Pittcon 2003. Les was very honoured to have given 4 oral lectures at Pittcon 2003 on Type C™ research that he was intimately involved with

Les first became involved in CCC instrument design in 1995, when a major pharmaceutical company in the UK, then called SmithKline Beecham, ask if Les could provide them with a CCC which would meet their safety / performance standards as no instrument then on the market did either. This instrument which was designed from a clean sheet of paper was the :-


THE QUATTRO COUNTER CURRENT CHROMATOGRAPH Mk 1



This was the first CCC with sophisticated, above and sub ambient temperature control.

 

 

 

 

 

 


History then repeated with the next client in UK then called Zeneca, not only requesting the above features but including an additional ' in house ' manual of additional safety features that no commercial CCC had previous offered. This instrument design became the Mk 2 and subsequently the slightly modified Mk 3.

 THE QUATTRO COUNTER CURRENT CHROMATOGRAPH Mk 2 & 3         
      

During the five year production of these instruments Les co-operated with a number of UK Universities including :- The University College of Swansea, Brunel University and University College of London.

In collaboration with the above Universities and with Shell Research, Astra Zeneca, Syngenta, GlaxoSmith Kline, Les co-operated in a $1,000,000 2 year joint Industry / Government sponsored UK research programme into the fundamental design of CCC and of generic method development strategies in CCC

In addition Les co-supervised / sponsored with Shell Research and AstraZeneca; PhD students in CCC methodology strategies for engine oil additives and chiral / diastereomer resolution at Swansea's world respected MassSpec Research Unit ( MSRU ).

More recently Les has collaborated on promoting seminars in CCC, initially CCC2000 held at Brunel University and more recently, Rio 2001, held at The Federal University of Rio, and organized by Prof. Dr. Gilda Leitao.

Major limitations in the flexibility for both production process scale-up and high resolution, rapid CCC were found with the earlier mono-chassis design of Quattro Mk 1, 2 & 3.

In early 2000, Robin Self, a design engineer with a lifetimes experience in instrumentation in the aerospace industry, joined the Quattro team to oversee a total revision of the Quattro concept, so as to allow a modular product range to be evolved, which would assure user methodology scale up from milligram to ton quantities.

Robin and his team, not only enhanced the fundamental design concept but also ensured safety and reliability standards the equal of any instrument company, as his inherent drive for engineering excellence, resulted in a quantum leap in standards well in excess of other CCC manufacturers and even earlier Quattro CCC models which now seem primitive by comparison to the new Mk 4

THE QUATTRO Mk 4 LABPREP

     

Because this design is intentionally modular, custom units with any user specified PTFE / Stainless Steel etc tubing with id's from 1 to 3.2 mm id can be specified ( others on request ). These instruments could have capacities of 600 ml to several litres as requested by the client. The Mk 4 can be had as laboratory instrument, The LabPrep, which has aluminum in it's construction and laboratory standard, CE ( etc ) standard electrical / mechanical design, or it can be purchased with an all non-aluminum construction ( a legal requirement for EEC and USA for instruments having 3 to 5 litres of solvent total capacity / usage ) and intrinsically safe electrical /electronic design.

The true excellence of THE QUATTRO MODULAR design is that high speed, low volume but high resolution small id coils can be had, or it is even possible to have multiple hybrid coils with various coil id's/od's and materials such as PTFE and stainless steel all on a match pair of bobbins. These are ideal for coil research optimisation.

                                                  

                                                   

Having optimised the coil / speed etc on the LabPrep the process can be moved to tonne per annum production without re-optimisation using the ProcessPrep with its bare stainless steel rotors for process applications ( with or with casework as required by client ). The ProcessPrep probably offers the most cost effective means of purification of any form of chromatography as it uses a half to a tenth the solvent of Prep HPLC / Flash Chromatography and yet costs a fraction of the price to establish and run..

THE QUATTRO PROCESS PREP  

                                           



Les, Robin and the Quattro team are still innovating in separation science by collaboration with Microsolv Technology Corporation ( where Les is Technical Director, overseeing the introduction of new HPLC phases for analytical, prep and process separations ) and Universities plus Research establishment throughout the world on novel CCC / HPLC / CE three dimensional generic strategies. For more information please visit the Microsolv website : - MicroSolvTech.com

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