Why use CCC
AECS-QuikPrep™ novel 2D preparative strategies
could achieve for your company, huge process etc cost savings. Laboratory
sized method development optimisation studies based on our QuikPrep™
CCC and HPLC / Flash Chromatography products can easily be scaled to multiple
tonne pre annum production.
Since that time the company has continued its core business of contract research method development and achiral plus chiral preparative / process chromatography.
Over twenty years later, AECS still offers these services in confidence, on a commercial, individual project basis.
In addition AECS has designed an evaporative light scatter detector, an LC-FID / LC-MS interface, plus possibly the world’s first peltier HPLC column chiller for chiral chromatography and several other projects.
Both instrumentation companies and blue chip non-instrumentation companies requiring custom production of instrumentation not commercially available, have contracted these projects.
From 1991, AECS in addition to the above, diversified into the supply and sale of chromatography consumables, plus novel instrumentation, both of it’s own design and imported niche products.
More recently AECS has assisted MicroSolv Technology
Inc., establish a range of micro-analytical, analytical and preparative
HPLC phases and column technologies. The HPS ( low trace metal end-capped
) / hQ ( low trace metal non end-capped ) type B ( Silanol surface ) and
the novel Type C™ ( Silica-Hydride surface ) phases have assisted
MicroSolv to diversify from one of the world’s major CE / CEC consumable
suppliers, into a new force in HPLC. MicroSolv was awarded recognition
for its unique patented Type C™ phases, being one of the most significant
new product releases at Pittcon 2003. Les was very honoured to have given
4 oral lectures at Pittcon 2003 on Type C™ research that he was
intimately involved with
Les first became involved in CCC
instrument design in 1995, when a major pharmaceutical company in the
UK, then called SmithKline Beecham, ask if Les could provide them with
a CCC which would meet their safety / performance standards as no instrument
then on the market did either. This instrument which was designed from
a clean sheet of paper was the :-
THE QUATTRO COUNTER CURRENT CHROMATOGRAPH Mk
2 & 3
the five year production of these instruments Les co-operated with a number
of UK Universities including :- The University College of Swansea, Brunel
University and University College of London.
In collaboration with the above Universities and with
Shell Research, Astra Zeneca, Syngenta, GlaxoSmith Kline, Les co-operated
in a $1,000,000 2 year joint Industry / Government sponsored UK research
programme into the fundamental design of CCC and of generic method development
strategies in CCC
In addition Les co-supervised / sponsored with Shell
Research and AstraZeneca; PhD students in CCC methodology strategies for
engine oil additives and chiral / diastereomer resolution at Swansea's
world respected MassSpec Research Unit ( MSRU ).
More recently Les has collaborated on promoting seminars
in CCC, initially CCC2000 held at Brunel University and more recently,
Rio 2001, held at The Federal University of Rio, and organized by Prof.
Dr. Gilda Leitao.
Major limitations in the flexibility for both production
process scale-up and high resolution, rapid CCC were found with the earlier
mono-chassis design of Quattro Mk 1, 2 & 3.
In early 2000, Robin Self, a design engineer with a lifetimes
experience in instrumentation in the aerospace industry, joined the Quattro
team to oversee a total revision of the Quattro concept, so as to allow
a modular product range to be evolved, which would assure user methodology
scale up from milligram to ton quantities.
Robin and his team, not only enhanced the fundamental
design concept but also ensured safety and reliability standards the equal
of any instrument company, as his inherent drive for engineering excellence,
resulted in a quantum leap in standards well in excess of other CCC manufacturers
and even earlier Quattro CCC models which now seem primitive by comparison
to the new Mk 4
Because this design is intentionally modular, custom
units with any user specified PTFE / Stainless Steel etc tubing with id's
from 1 to 3.2 mm id can be specified ( others on request ). These instruments
could have capacities of 600 ml to several litres as requested by the
client. The Mk 4 can be had as laboratory instrument, The LabPrep, which
has aluminum in it's construction and laboratory standard, CE ( etc )
standard electrical / mechanical design, or it can be purchased with an
all non-aluminum construction ( a legal requirement for EEC and USA for
instruments having 3 to 5 litres of solvent total capacity / usage ) and
intrinsically safe electrical /electronic design.
Having optimised the coil / speed etc on the LabPrep
the process can be moved to tonne per annum production without re-optimisation
using the ProcessPrep with its bare stainless steel rotors for process
applications ( with or with casework as required by client ). The ProcessPrep
probably offers the most cost effective means of purification of any form
of chromatography as it uses a half to a tenth the solvent of Prep HPLC
/ Flash Chromatography and yet costs a fraction of the price to establish